Mild traumatic brain injuries (mTBIs) are the most common form of TBI. A majority of mTBI patients develop a migraine-like headache called post-traumatic headache (PTH). To date, there are no PTH-specific therapeutics. To better understand PTH, I developed a mouse model of PTH and explored the effect of mTBI on calcitonin gene-related peptide (CGRP), a pro-migraine peptide. I also tested current anti-migraine therapeutics and a novel, promising drug target.